Immunofluorescent confocal micrograph of a day 10.5 mouse limb bud (blue marks fibroblasts, green indicates epithelial cells, red denotes dividing cells)
Skeletal preparation of the cranial vault of a day 18.5 mouse embryo (blue denotes cartilage, while purple indicates mineralized bone)
Whole-mount Alkaline Phosphatase staining of a day 10.5 mouse embryo, reporting Boc gene expression
Congratulations to our colleagues in the laboratory of Thomas Willnow for publishing an exciting story in Development defining a novel role for GAS1 in facilitating NOTCH signaling, and in the integration of NOTCH and SHH signaling during forebrain development. It was a pleasure to collaborate with our colleagues at the Max Delbrueck Center for Molecular Medicine on this important work. Read more here.
Congratulations to Bridget Waas for being invited to present a seminar at Illinois State University in the Neuroscience and Physiology program on her thesis research, entitled, “Dual and Opposing Roles for KIF17 in Hedgehog-driven Cerebellar Development”. Congratulations Bridget!!
Congratulations to Allen Lab Alumnus Brandon Carpenter for his Appointment as Assistant Professor of Molecular and Cellular Biology at Kennesaw State University! read more here: https://facultyweb.kennesaw.edu/bcarpe18/
Congratulations to Nina Steele for receiving an NIH K99/R00 Pathway to Independence Award titled, “Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer” August 2021
In the developing mouse neural tube, Sonic Hedgehog (Shh) is initially expressed in the notochord (NC) underlying the ventral neural tube; as development progresses, Shh auto-induces a secondary domain of Shh production within the floor plate (FP) of the neural tube at the ventral midline. Several lines of evidence indicate that Shh acts in a concentration dependent manner to specify all ventral cell types of…
Kumari A1, Ermilov AN2, Grachtchouk M2, Dlugosz AA2,3, Allen BL3, Bradley RM1, Mistretta CM4. Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib, Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10369-E10378. doi: 10.1073/pnas.1712881114. Epub 2017 Nov 13. Please see the PDF version here.